Biology Chronic Kidney Disease Paper

Want create site? With you can do it easy.

Biology Chronic Kidney Disease Paper

Chronic kidney disease is a gradual loss of kidney function. you will explore this disease in more detail using the scenario below.Scenario:

Struggling to find relevant content or pressed for time? – Don’t worry, we have a team of professionals to help you on
Biology Chronic Kidney Disease Paper
Get a 15% Discount on this Paper
Order Now

Your parent has recently been diagnosed with chronic kidney disease. Your parent is confused about what this means and asks you to help them navigate their care. You decide to research the disease to help support your parent..To complete this , do the following:1. Research this disease using a minimum of 2 source(s). You can use your textbook for one of the sources. Choose the remaining sources from the GALE Virtual Reference Library provided on the.2 address the following:Explain how chronic kidney disease develops and the potential causes.Describe the treatment options that exist.

research sourcesDavidson, Tish. “Kidney Disease.” The Gale Encyclopedia of Medicine, edited by Jacqueline L. Longe, 5th ed., vol. 5, Gale, 2015, pp. 2851-2853.Davidson, Tish. “Kidney Disease.” The Gale Encyclopedia of Medicine, edited by Laurie J. Fundukian, 4th ed., vol. 3, Gale, 2011,pp. 2475-2478.Woldin, Barbara. “End-Stage Renal Disease.” Magill’s Medical Guide, edited by Bryan C. Auday, et al., 7th ed., vol. 2, Salem Press, 2014, pp. 749-751.

The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis in the human body. The combination of distinct, yet interrelated, molecular functions across different cell types make the delineation of factors associated with loss or decline in kidney function challenging. Consequently, there has been a paucity of new diagnostic markers and treatment options becoming available to clinicians and patients in managing kidney diseases. A systems biology approach to understanding the kidney leverages recent advances in computational technology and methods to integrate diverse sets of data. It has the potential to unravel the interplay of multiple genes, proteins, and molecular mechanisms that drive key functions in kidney health and disease. The emergence of large, detailed, multilevel biologic and clinical data from national databases, cohort studies, and trials now provide the critical pieces needed for meaningful application of systems biology approaches in nephrology. The purpose of this review is to provide an overview of the current state in the evolution of the field. Recent successes of systems biology to identify targeted therapies linked to mechanistic biomarkers in the kidney are described to emphasize the relevance to clinical care and the outlook for improving outcomes for patients with kidney diseases.

Biology Chronic Kidney Disease Paper

Biology Chronic Kidney Disease Paper

Why Is a Systems Approach Needed to Tackle Kidney Diseases?
The kidney plays a central role in maintaining homeostasis in the human body. To successfully carry out these functions, the kidney contains numerous cell types arranged in the complex three-dimensional structure of the nephron to respond to a variety of hormonal, neuronal, inflammatory, and intra- and intercellular signals. The network of complex, intertwined regulatory functions across different cell types make the delineation of specific mechanism associated with loss or decline in kidney function challenging. Clinical trials for the development of diagnostic markers and novel therapies targeting kidney diseases have consequently been limited (1–⇓3), resulting in few prevention and treatment options available to clinicians and patients.

Much of our knowledge of kidney physiology and pathophysiology has been gleaned from a reductionist approach, where careful experimentation has elucidated the effect of one molecular pathway on kidney health and disease, mostly in animal models. However, many kidney diseases, most notably CKD and AKI, comprise diseases of multiple etiologies. Thus, patients enrolled in clinical trials often have heterogeneous disease mechanisms activated, which has likely contributed to the low success rate of clinical trials of pathway-specific targets in nephrology. Biomarkers to further classify subgroups of patients, thus far, have focused more on clinical features rather than on molecular mechanisms that might indicate efficacy of putative therapies. Integrating a wide spectrum of information on the underlying disease mechanism using a systems biology approach has the potential to addresses some of these challenges. This strategy leverages our existing granular knowledge obtained through traditional reductionist approaches toward a holistic understanding of disease processes in a given patient.

A global, or systems biology, approach takes advantage of recent developments in computational methods to integrate diverse types of data, such as molecular, tissue, and clinical parameters, to unravel the interplay of multiple genes, proteins, and molecular mechanisms (Figure 1) that drive discrete steps in kidney health and disease (4,5). A core element of this strategy is the integration of various data sources, including conventional clinical phenotypic patient data, clinicopathologic parameters, and comprehensive genome-scale data sets (also referred to as “omics”) through bio-informatics analytical workflows. Integrating such diverse data into analytical processes necessitate the blending of a variety of expertise including clinical, biologic, information technology, mathematical, statistical, and computational research in nephrology research teams. Sophisticated information technology infrastructure is required to manage and connect information across research and health care. Meanwhile, software tools for analysis and interpretation of data need “integrative workflows” that involve a combination of statistical, computational, and mathematical techniques (6,7). The purpose of this review is to provide an overview of the current state in the evolution of systems biology for the nephrologist. By highlighting the advances made through this approach toward developing targeted therapies linked to mechanistic biomarkers, the potential effect on clinical care and improving outcomes for patients with kidney diseases are discussed (8–⇓10).

Did you find apk for android? You can find new and apps.

Calculate the price
Make an order in advance and get the best price
Pages (550 words)
$0.00
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Pro service tips
How to get the most out of your experience with MyCoursebay
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
Testimonials
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Criminal law
Thank You!
Customer 452465, January 29th, 2021
Mental Wellness
The skilled writer did a good job. I will add a few more details. Thank you, great job...
Customer 452547, June 17th, 2021
Nursing
Perfectly done!
Customer 452707, July 18th, 2022
Social Work and Human Services
Good Work!
Customer 452587, September 2nd, 2021
Nursing
Always perfect! Thank you!!!
Customer 452453, April 15th, 2021
Business and administrative studies
GOOD
Customer 452813, June 30th, 2022
Management
Great job
Customer 452643, October 31st, 2021
Social Work and Human Services
Excellent Work
Customer 452587, November 22nd, 2021
English 101
I'm glad i came to you guys
Customer 452519, May 11th, 2021
Nursing
Great! Thanks again!
Customer 452707, July 4th, 2022
Philosophy
The paper is great. Will definitely use again.
Customer 452773, May 24th, 2022
Nursing
Great work! I can tell they put great effort in completing this assignment. Thank you.
Customer 452707, October 14th, 2022
11,595
Customer reviews in total
96%
Current satisfaction rate
3 pages
Average paper length
37%
Customers referred by a friend
OUR GIFT TO YOU
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat

Get your perfect essay with a 15% discount. Use DC15

NEW

Thank you for choosing MyCoursebay. Your presence is a motivation to us. All papers are written from scratch. Plagiarism is not tolerated. Order now for a 15% discount

Order Now