[SOLVED] Response 1 Fluoroquinolones: As a widely prescribed antibiotic

Response 1 Fluoroquinolones: As a widely prescribed antibiotic, fluoroquinolones are used for the purpose of treating pneumonias, UTI’s, bronchitis, and sinusitis issues (Golomb, Koslik, & Redd, 2015). The pharmacokinetic property of fluoroquinolones is that they distributed throughout the body through the extracellular and intracellular fluids and concentrate in the lungs, prostate and bile (Werth, 2018). The Pharmacodynamic aspect of fluoroquinolones is that they work by targeting bacterial enzymes called DNA gyrase and topoisomerase IV. This action makes it hard for bacteria to multiply within the body, enhancing the effectiveness of this drug (Robinson & Woo, 2015). Antilipidemics The pharmacokinetic aspect of antilipidemic drugs, or statins, is that they are absorbed in the body through the liver, therefore increasing the livers ability to remove the bad cholesterol in the body. The pharmacodynamic aspect of statins are that they inhibit the enzyme HMG-CoA reductase and therefore controls the rate of cholesterol production in the body (Robinson & Woo, 2015). When a patient is taking a statin, the effects are often shown to decrease the intracellular production of cholesterol. This was shown in a study of patients who were infected with HIV, and wanted to understand statin effects and protein regulation (Filippi et al., 2020). Response 2   The Factors that Influence the Pharmacokinetics and Pharmacodynamics — Selective Serotonin Inhibitors and ACE Inhibitors             Selective Serotonin and ACE Inhibitors are some of the popular groups of drugs. In this case, selective Serotonin Inhibitors such as citalopram, fluvoxamine, and escitalopram are administered in treating depression. They limit the blood from absorbing serotonin from the brain. The increase in this neurochemical in the brain relieves the level of depression (Woo, & Robinson, 2020). The pharmacokinetics of Angiotensin-converting enzyme inhibitors (ACEI) entails relaxing the blood vessels, resulting in low blood pressure. The ACEI prevents body enzymes from secreting angiotensin II, which is often responsible for vasoconstrictions of blood vessels associated with elevated blood pressure. Pharmacokinetics and pharmacodynamics of both drugs are subject to various factors, including genetics and patient demographics.             For instance, the effectiveness of Selective Serotonin Inhibitors (SSIs) can be influenced by psychological factors like trait and state of anxiety and genetic factors. For instance, Tracy et al. (2016) explain that the metabolism of SSRIs is initiated by P450 (CYP) enzymes of the liver, which vary genetically to the extent that they affect the rate at which the drug is cleared. Indeed, the study by Maggo et al. (2019) revealed significant differences in correspondence between CYP2D6, CYP2C19, and CYP2C9 phenotypes of participants and history of tolerability of the antidepressant.  Genetics also plays a crucial role in the pharmacokinetics and pharmacodynamics of ACE inhibitors. As documented by Flaten and Monte (2017), the ACE gene comes in variants associated with deletion, insertion of repetitions of Alu typical to intron 16. These variations have been linked to myocardial infarctions. A study on Malayan patients revealed that ACE can be effective for D/D genotype patients, as it is characterized by elevated ACE serum levels and activity that supports the inhibition process. The effectiveness is also subject to patient demographics such as gender. For instance, the rate of Angioedema, a common side effect, is common among women than men. This difference is attributable to the role of the C2399A variant among women. Moreover, ACE gene variants such as rs4267385 and rs4459610 are a protective factor against side effects such as coughs (Flaten and Monte, 2017). Therefore, physicians need to consider these factors when administering these drugs.   Your responses should be in a well-developed paragraph (300-350 words) to each peer. Integrating an evidence-based resource that is different than the one you used for the initial post. Your responses to each peer’s chosen drug categories should include one evidence-based article that connects culture, genomics, pharmacogenomics, or a particular age group (infant or pregnancy, for example.)

 

Struggling to find relevant content or pressed for time? – Don’t worry, we have a team of professionals to help you on
[SOLVED] Response 1 Fluoroquinolones: As a widely prescribed antibiotic
Get a 15% Discount on this Paper
Order Now

Can’t find relevant content? Don’t worry– you have a team of professionals to help you.

All you need to do is fill in the order form in the upper right corner and upload the files that are crucial for your assignment. Also, don’t forget to specify whether your assignment has to be based upon a specific research, theory or method. After that, we will assign an expert to complete your order. You can always chat with your expert and ask any questions you have during the working process.

Calculate the price
Make an order in advance and get the best price
Pages (550 words)
$0.00
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Pro service tips
How to get the most out of your experience with MyCoursebay
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
Testimonials
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Nursing
Thank you so much for being the best website for assignment help.
Customer 452635, June 24th, 2022
Nursing
The writer went above and beyond for this assignment. I am so grateful for the help.
Customer 452707, August 19th, 2022
Human Resources Management (HRM)
Thank you
Customer 452531, May 19th, 2021
Other
great
Customer 452813, June 25th, 2022
Nursing
Thank you!!!
Customer 452557, June 26th, 2021
Criminal Justice
always great!
Customer 452465, February 23rd, 2021
Other
NICE
Customer 452813, June 30th, 2022
Social Work and Human Services
Excellent Work!
Customer 452587, November 30th, 2021
Nursing
Thank you!
Customer 452707, April 3rd, 2022
Nursing
Great writer (Proske). I highly recommend
Customer 452531, July 10th, 2021
Other
GOOD
Customer 452813, July 5th, 2022
Other
great
Customer 452813, June 30th, 2022
11,595
Customer reviews in total
96%
Current satisfaction rate
3 pages
Average paper length
37%
Customers referred by a friend
OUR GIFT TO YOU
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat

Get your perfect essay with a 15% discount. Use DC15

NEW

Thank you for choosing MyCoursebay. Your presence is a motivation to us. All papers are written from scratch. Plagiarism is not tolerated. Order now for a 15% discount

Order Now