Sickle Cell Disease Critique Template
Sickle Cell Disease Critique Template
Not all-inclusive if you have another idea, but arent sure if it fits under the biotech umbrella, please email me or stop by with a copy of the article. Remember, if it is not on this list, it must be pre-approved.
Articles used for journal critiques must be research articles (clinical trial, case reports or meta-analyses), not review or continuing education articles.
Note that these topics would also apply for the popular media critiques, and many of the general topics would be good ideas for the fictional critiques (i.e. books/movies such as Boys from Brazil and Jurassic Park deal with cloning, Gattaca deals with genetic engineering and testing).
General topics:
Biosimilars
Stem cell research
Cloning
Genetically modified food or animals / Biopharming
Polymerase chain reaction
Blotting techniques (southern, northern, western)
Pharmacogenomics
Biotech techniques as used in forensics / DNA profiling
Genome editing
Gene therapy
RNA interference / RNAi
Antisense / morpholinos
CAR-T
Genetic testing
Neutralizing antibodies as potential Covid treatment; testing methods for such antibodies
Hematopoietic growth factors
Filgrastim (Neopogen®, Zarxio®)
Pegfilgrastim (Neulasta®)
Tbo-filgrastim (Granix®)
Sargramostim (Leukine®)
Erythropoietin (Epogen®, Procit®)
Darbapoetin (Aranesp®)
Cytokines and Antagonists
Interleukins
? Interleukin-2 (Proleukin®)
? Interleukin-11 (Neumega®)
? Denileukin Difitox (Ontak®)
Interferons
? Interferon alpha-2a (Roferon®, Pegasys®)
? Interferon alpha-2b (Intron A®, Rebetron®, PEG-Intron®)
? Interferon alfacon-1 (Infergen®)
? Interferon alfa-N3 (Alferon N®)
? Interferon beta-1a (Rebif®, Avonex®)
? Interferon beta-1b (Betaseron®, Extavia®)
? Interferon gamma-2b (Actimmune®)
? Interferon lambda (in development)
Interleukin / TNF antagonists
? Anakinra (Kineret®)
Becaplermin (Regranex®)
Hormones (derived from biotechnology sources only)
Glucagon (GlucaGen®, Baqsimi®, Gvoke®)
Inhaled insulin (Afrezza®)
Buccal insulin (Oral-lyn®)
Growth hormone
? Somatrem (Protropin®)
? Somatropin (Humatrope®, Nutropin®, Saizen®, Serostim®)
Follicle-stimulating hormone
? Follitropin alpha (Gonal-F®)
? Follitropin beta (Follistim®)
Enzymes (Partial list. Only recombinant enzymes are acceptable)
Alteplase (Activase®)
Asfotase alfa (Strensig®)
Avalglucosidase alfa-ngpt (Nexviazyme®)
C1 esterase inhibitor (Ruconest®)
Cerliponase alfa (Brineura®)
Dornase alpha (Pulmozyme®)
Drotrecogin alpha (Xigris®) no longer on market
Elosulfase alfa (Vimizim®)
Imiglucerase (Cerezyme®)
Pegaspargase (Oncaspar®)
Pegloticase (Krystexxa®)
Pegvaliase-pjpz (Palynziq)
Retaplase (Retevase®)
Sebelipase alfa (Kanuma®)
Tenecteplase (TNKase®)
Coagulation and anti-coagulation factors
Antihemophilic Factor / von Willebrand Factor complex (Humate-P®)
Antihemophilic Factor (recombinant) Fc Fusion Protein1 (Eloctate)
Bivalirudin (Angiomax®)
Desirudin (Ipravask®)
Eptifibatide (Integrilin®)
Factor VIIa (NovoSeven®)
Factor VIII (Advate®, Eloctate®, Helixate®, Kogenate FS®, Novoeight®, Recombinate®, Xyntha®, Nuwiq®)
Factor IX (Alprolix®, Rixubis®, Benefix®, Ixinity®)
Lepirudin (Refludan®)
von Willebrand Factor (Vonvendi®)
Sickle Cell Disease Critique Template
Monoclonal antibodies and fusion proteins (may include others in development; biosimilar names not included here)
Abatacept (Orencia®)
Abciximab (Reopro®)
Adalimumab (Humira®)
Ado-trastuzumab emtansine (Kadcyla®)
Aducanumab (in development)
Aflibercept (Eylea®)
Alemtuzumab (Campath-1H®, Lemtrada®)
Alirocumab (Praluent®)
Amatuximab in development
Amivantamab-vmjw (Rybrevant®)
Anifrolumab (Saphnelo®)
Atezolizumab (Tecentriq®)
Avelumab (Bavencio®)
Basiliximab (Simulect®)
Belatacept (Nulojix®)
Belimumab (Benlysta®)
Benralizumab (Fasenra®)
Bevacizumab (Avastin®)
Bezlotoxumab (Zinplava®)
Blinitumomab (Blincyto®)
Brentuximab vedotin (Adcetris®)
Brodalumab (Siliq®)
Burosumab-twza (Crysvita®)
Canakinumab (Ilaris®)
Caplacizumab-yhdp (Cablivi®)
Cemiplimab-rwlc (Libtayo®)
Certolizumab (Cimizia®)
Cetuximab (Erbitux®)Crizanlizumab-tmca (Adakveo®)
Daclizumab (Zenapax®, Zinbryta®)
Daratumumab (Darzalex®)
Denosumab (Prolia®, Xgeva®)
Dinutuxumab (Unituxin®)
Dostarlimab (Jemperli®)
Dupilumab (Dupixent®)
Eculizumab (Soliris®)
Elotuzumab (Empliciti®)
Emapalumab-lzsg (Gamifant®)
Emicizumab-kxwh (Hemlibra®)
Epratuzumab in development
Erenumab-aooe (Aimovig®)
Eternacept (Enbrel®)
Evolocumab (Repatha®)
Fremanezumab-vfrm (Ajovy®)
Galcanezumab-gnlm (Emgality®)
Golimumab (Simponi®)
Guselkumab (Tremfya®)
Ibalizumab-uiyk (Trogarzo®)
Ibritumomab tiuxetan (Zevulin Y-90®)
Idarucizumab (Praxbind®)
Infliximab (Remicade®)
Inotuzumab ozogamicin (Besponsa®)
Ipilumomab (Yervoy®)
Ixekizumab (Taltz®)
Lanadelumab-flyo (Takhzyro®)
Luspatercept-aamt (Reblozyl®)
Mepolizumab (Nucala®)
Mogamulizumab-kpkc (Poteligeo®)
Moxetumomab pasudotox-tdfk (Lumoxiti®)
Natalizumab (Tysabri®)
Necitumumab (Portrazza®)
Nivolumab (Opdivo®)
Obiltoxaximab (Anthim®)
Obinutuzumab (Gazyva®)
Ocrelizumab (Ocrevus®)
Ofatumumab (Arzerra®)
Olaratumab (Lartruvo®)
Omalizumab (Xolair®)
Palivizumab (Synagis®)
Panitumumab (Vectibix®)
Pembrolizumab (Keytruda®)
Pertuzumab (Perjeta®)
Polatuzumab vedotin-piiq (Polivy®)
Ramucirumab (Cyramza®)
Ranibizumab (Lucentis®, Susvimo®)
Ravulizumab-cwvz (Ultomiris®)
Raxibacumab
Reslizumab (Cinqair®)
Rilonacept (Arcalyst®)
Risankizumab-rzaa (Skyrizi®)
Rituximab (Rituxan®)
Romosozumab-aqqg (Evenity®)
Sarilumab (Kevzara®)
Secukinumab (Cosentyx®)
Siltuximab (Sylvant®)
Tildrakizumab-asmn (Ilumya®)
Tocilizumab (Actevma®)
Trastuzumab (Herceptin®)
Ustekinumab (Stelara®)
Vedolizumab (Entyvio®)
Ziv-aflibercept (Zaltrap®)
Zmapp (trio of monoclonals for ebola) in development
Antisense oligonucleotides (topic in general, or one of products below):
Affinitak
Alicaforsen (Camligo®)
Eteplirsen (Exondys 51)
Fomiversen (Vitravene®)
Mipomersen (Kynamro®)
Nusinersen (Spinraza®)
Oblimersen (Genasense®)
RNA interference (topic in general, or product below):
Patisiran (Onpattro®)
Gene therapies (topic in general, or one of products below):
Axicabtagene ciloleucel (Yescarta®)
Talimogene laherparepvec (Imlygic®)
Voretigene neparvovec-rzyl (Luxturna®)
Other products produced by genetic engineering, recombinant or gene-editing methods
Sipuleucel-T (Provenge®) recombinant cancer vaccine
Tisagenlecleucel (Kymriah®)
